The following methods can also synthesize 1-phenyl-2-acetone: the synthesis of phenylacetone
Add 26.67g (0.20mol) powdered anhydrous aluminum trichloride and 36mL (0.40mol) anhydrous benzene to the reaction bottle, slowly add l0mL(0.l0mol) phenylacetyl chloride under stirring, and cool down in a cold water bath. After feeding, heat it in an oil bath of about 95℃ and stir for reflux until no more hydrogen chloride gas escapes. Cool the reactant to room temperature and pour 65mL of concentrated hydrochloric acid and 80g of crushed ice in a conical bottle under stirring. CHCl3 extracts the organic phase, and then wash the organic phase with 20mL water, 8mL 20% NaOH and 20mL water in turn, dry and filter the anhydrous sodium sulfate, rotate and evaporate to remove CHCl3, and collect the distillation of 68-70C/-F by decompression distillation to obtain 11.12g of colorless liquid. The yield is 75%, Rf=0.68 (silicone plate chromatography, chloroform as unfolding agent).
Add 26.67g (0.20mol) powdered anhydrous aluminum trichloride and 36mL (0.40mol) anhydrous benzene to the reaction bottle, slowly add l0mL(0.l0mol) phenylacetyl chloride under stirring, and cool down in a cold water bath. After feeding, heat it in an oil bath of about 95℃ and stir for reflux until no more hydrogen chloride gas escapes. Cool the reactant to room temperature and pour 65mL of concentrated hydrochloric acid and 80g of crushed ice in a conical bottle under stirring. CHCl3 extracts the organic phase, and then wash the organic phase with 20mL water, 8mL 20% NaOH and 20mL water in turn, dry and filter the anhydrous sodium sulfate, rotate and evaporate to remove CHCl3, and collect the distillation of 68-70C/-F by decompression distillation to obtain 11.12g of colorless liquid. The yield is 75%, Rf=0.68 (silicone plate chromatography, chloroform as unfolding agent).