PSE extraction

[Urky]

Hello good people, I would like you to suggest some idea for my proble.
In my country we dont have "pure" pse pill anymore we have Modafen.
So these pills contain pse and ibuprofen.
My idea is to extract pse with very cold water because ibuprofen isnt soluable in cold water but then what?
if I evaporate water i would destroy my yield a lot am i right ?

 

[Urake123]

I would like to know it too.

 

[biotechwix]

tetrachloroethylene

 

[Urky]

tetrachloroethylene

biotechwixyour advice is to disolve it in tetrachloroethylene ?

 

[biotechwix]

soak the pill mass with tetra but you know i used the tetra with those pillz which contained povidone.
btw brother im only a low level wannabee cook but you are out of your mind thinking of soak the pillz with water..
you can do that in the early 90's with old red hot.
stop before waste pillz.
also it should be really intelligent if you research pillz cleaning tecniques because im under the impression that you went for some write ups from the underground hive era.
cold water.NO
you need solvents and btw if you are in EU you can order from the internet the white 60s with cetirizine which in my experience are the ones which you can extract
or the 120 with povidone.

 

[hacke8]

soak the pill mass with tetra but you know i used the tetra with those pillz which contained povidone.
btw brother im only a low level wannabee cook but you are out of your mind thinking of soak the pillz with water..
you can do that in the early 90's with old red hot.
stop before waste pillz.
also it should be really intelligent if you research pillz cleaning tecniques because im under the impression that you went for some write ups from the underground hive era.
cold water.NO
you need solvents and btw if you are in EU you can order from the internet the white 60s with cetirizine which in my experience are the ones which you can extract
or the 120 with povidone.

biotechwixPlease help me, sir.
Hello fellow chemists. Today I brought a cold medicine (capsule) containing pseudoephedrine hydrochloride. There are 8 capsules in a box. Each capsule contains 90 mg of pseudoephedrine, totaling 0.72 grams. It is very cheap at US$1.5. Here are its ingredients: Each capsule contains 90 mg of pseudoephedrine hydrochloride. mg, chlorpheniramine maleate (chlorpheniramine) 4 mg. The auxiliary materials are: starch, sucrose, hydroxypropyl methylcellulose, ethyl cellulose polymer, Opadry yellow dry spray material, Opadry pink dry spray material. How can I maximize extraction?
My own extraction steps are: open the capsule - soak in 99% ethanol - suction filtration - evaporate the filtrate to the extract - add cold water to the extract (glue will appear) - suction filtration - adjust the filtrate to alkali PH12+ and then extract, (xylene ) Dry the extract - after drying, pass in hydrogen chloride gas (the pH reaches acidity) - filter with suction to obtain white pseudoephedrine hydrochloride powder. But I tried several extractions and only got very little pseudoephedrine. Is there any way to increase the yield?

 

[hacke8]

soak the pill mass with tetra but you know i used the tetra with those pillz which contained povidone.
btw brother im only a low level wannabee cook but you are out of your mind thinking of soak the pillz with water..
you can do that in the early 90's with old red hot.
stop before waste pillz.
also it should be really intelligent if you research pillz cleaning tecniques because im under the impression that you went for some write ups from the underground hive era.
cold water.NO
you need solvents and btw if you are in EU you can order from the internet the white 60s with cetirizine which in my experience are the ones which you can extract
or the 120 with povidone.

biotechwixMy method can only extract 42% of the yield. I don't know where I missed it.

 

[xile]

Check out the form in which pse and ibu appear in it. pse hcl is water soluble, ibu in normal form is not. So I think it could be filtered

 

[Urky]

Check out the form in which pse and ibu appear in it. pse hcl is water soluble, ibu in normal form is not. So I think it could be filtered

xileyeah i know but my pills contain shit which activates when using water

 

[stim2023]

Red 30mg generic PSE in USA was extracted using dry solvent extraction as of 5 days ago which after 3 pulls and HCL gassing had a net amount of 2.58gr (I box 96ct) CLEAN PSE hcl. The trick is ZERO WATER

 

[Urky]

thanks you all for every advice but im still desperate....
biotechwix thanks for sazing no water.....do you know about any legit website for ephedrine
thank you xile for advice to use water but as i said my pills would get detroyed if im using water
and thankyou stim2023 for sazing no water but zour american pills contain onlz PSE and some other fillers.
my WORST nightmare is that frickin ibuprofen xd

 

[wael gano]

thanks you all for every advice but im still desperate....
biotechwix thanks for sazing no water.....do you know about any legit website for ephedrine
thank you xile for advice to use water but as i said my pills would get detroyed if im using water
and thankyou stim2023 for sazing no water but zour american pills contain onlz PSE and some other fillers.
my WORST nightmare is that frickin ibuprofen xd

UrkyIt's very simple. All you have to do is separate the acid from the base
Pseudoephedrine is an amine
Ibuprofen carboxylic acid
Grind the tablets and dissolve them in water, then make a water solution of 25% sodium hydroxide and add a little to adjust the pH 12.
Then add toluene and extract the pseudoephedrine base. Separate the toluene from the water. Now you have the base dissolved in the toluene. Pump hydrogen chloride gas into the toluene. The pseudoephedrine hydrochloride salt will precipitate.

 

[Urky]

It's very simple. All you have to do is separate the acid from the base
Pseudoephedrine is an amine
Ibuprofen carboxylic acid
Grind the tablets and dissolve them in water, then make a water solution of 25% sodium hydroxide and add a little to adjust the pH 12.
Then add toluene and extract the pseudoephedrine base. Separate the toluene from the water. Now you have the base dissolved in the toluene. Pump hydrogen chloride gas into the toluene. The pseudoephedrine hydrochloride salt will precipitate.

wael ganoThank for answering.
But im wondering....wouldnt it activate the anti extraction sh...ts ?

 

[wael gano]

Thank for answering.
But im wondering....wouldnt it activate the anti extraction sh...ts ?

UrkyActivate what Please list the materials you would like to separate

 

[Urky]

Activate what Please list the materials you would like to separate

wael ganoThank you a lot i will give you a list of materials. If you can find any solution how to seperate just PSE I would be so glad

 

[Frit Buchner]

Uhhh, you guys know that this drug isn't even very close to pseudoephedrine right? This drug also is not soluble in water it's
2‑[(Diphenylmethyl)sulfinyl]acetamide

 

[BennyBlanco]

So what's the final answer. Should we give up on the idea of extracting from Modafen ? (Because junkies in my country somehow cook with this s***) I have the same problem now and don't want to make another post about the same topic so what's the solution to this problem?

 

[Frit Buchner]

So what's the final answer. Should we give up on the idea of extracting from Modafen ? (Because junkies in my country somehow cook with this s***) I have the same problem now and don't want to make another post about the same topic so what's the solution to this problem?

SpiritusDilutus100gYou just need a different tactic. The procedures used ro reduce ephedrine are not going to make anything useful with this chemical. There are useful things to be made with it though. This paper outlines a 1 step reaction that makes it 10x stronger at DAT this is something to look at https://pubs.acs.org/doi/10.1021/jm401754x

 

[BennyBlanco]

You just need a different tactic. The procedures used ro reduce ephedrine are not going to make anything useful with this chemical. There are useful things to be made with it though. This paper outlines a 1 step reaction that makes it 10x stronger at DAT this is something to look at https://pubs.acs.org/doi/10.1021/jm401754x

Frit BuchnerThank you for the answer i will definitely look at it. But just to let you know i am a total beginner so in some high level chemistry i will be totally lost. That's why i need somone to explain it to me like to a 12 year old. But anyway i am very glad that you tried to help me thanks

 

[Frit Buchner]

Thank you for the answer i will definitely look at it. But just to let you know i am a total beginner so in some high level chemistry i will be totally lost. That's why i need somone to explain it to me like to a 12 year old. But anyway i am very glad that you tried to help me thanks

SpiritusDilutus100gIt appeared to me that it is even easier than an ephedrine pseudoephedrine reduction. As I recall you are started at 4f (that's the chemical you are trying to extract fromthese pills) and you can go to 5g in 1 step, just look for those numbers in the experimental section of the paper

 

[stim2023]

Thank you for the answer i will definitely look at it. But just to let you know i am a total beginner so in some high level chemistry i will be totally lost. That's why i need somone to explain it to me like to a 12 year old. But anyway i am very glad that you tried to help me thanks

BennyBlancoReal talk you don't need someone to hold your hand... What you truly need is to become independent of asking people on forums or other and learning the chemistry behind what you are truly aiming to do. If one were to spoon feed you every step and every synthesis it's a lot like being taught to fish but being shit out of luck because you borrowed someone else's equipment rather than become self sufficient and dependent on yourself. Once you learn the why and the how you can be on your way to genuine progress.