Amphetamine synthesis from P2NP via Al/Hg (video)

[HIGGS BOSSON]

Is there any specific reason to prefer isopropanol over ethanol?

laymanIsopropanol is cheaper and more legal, in some countries it is difficult to buy ethanol due to legislative restrictions, but it can also be used in this synthesis.

 

[G.Patton]

I was going to try to use this guide in the future to make it L-PAC ? https://www.thevespiary.org/talk/index.php?topic=12453.0

I am totally novice to chemistry but I know I can put the pieces together, with your guys help

So hopefully L-PAC with the process above could be a great fun experiment

ifreezeuI can help you with synthesis, you can ask me in private messages any question about.

 

[chubaca]

In the video synthesis of amphetamine, reagents are used:
10 g 1-phenyl-2-nitropropene;
100 ml isopropyl alcohol;
50 ml glacial acetic acid;
50 g sodium hydroxide;
12 g aluminium (in the form of sliced household foil);
0.1g mercury nitrate;
2 ml sulphuric acid;
50 ml acetone.

Description of amphetamine synthesis video.
Before the start of the synthesis, the laboratory assistant prepared a solution of 10 g of 1-phenyl-2-nitropropene in 100 ml of isopropyl alcohol and 50 ml of acetic acid. Also, for the aluminium amalgam, 12 g of household aluminium foil was prepared, which was cut into small pieces with a paper shredder. It can be cut with scissors or torn by hand.

0:04-0:40 - Preparation of an aqueous solution of alkali. In this video, it was made in advance so that the solution cools down by the time the main reaction mixture alkalizes. Alkalinization proceeds with the release of heat, and if a fresh hot alkali solution is used, then the exothermic will be more pronounced and forced cooling of the reaction mass will be required.

0:46-2:36 - Amalgam of mercury nitrate. Amalgamated aluminium will reduce 1-phenyl-2-nitropropene to amphetamine. During the amalgamation reaction: little gas evolves, a grey precipitate is formed. It is important not to miss the moment when the aluminium is ready: this can be determined by the formation of a grey precipitate and by the increased gas evolution; this happens in 10-15 minutes after the load.
The water is drained without removing the gauze, the amalgamated aluminium is washed with two portions of cold water. It is worth paying attention to the release of gas bubbles: it is noticed that with the "correct" amalgam, these bubbles are small, and the colour of the liquid is darker; if the bubbles are large and the colour is light, and the reaction looks violent, the amalgam is bad. This is almost certainly due to a lack of mercury salt. Please note that mercury salts are poisonous.

2:37-4:28 - The most important part of the process is the reduction of 1-phenyl-2-nitropropene on aluminium amalgam. The reaction is exothermic, proceeds with abundant heat release. During the process, it is necessary to carefully monitor the temperature, in case of excessive overheating, to cool in an ice bath, it is allowed to add cold water to the flask. There are cases when the reaction does not start, in which case it is necessary to warm the reaction mass thoroughly, and with a properly prepared amalgam, the reaction begins. The reaction proceeds with the release of the smell of a boiling alcohol and acetic acid mixture. To capture vapours, a spherical irrigation condenser is used, the efficiency of which can be increased by connecting running cold water to it or simply pouring cold water into.

5:04 - You can rinse the flask with a little alcohol and rinse the unreacted aluminium with it to collect residues and increase the yield.

5:13 - There should be little unreacted aluminium left. By the residues, you can determine the amount of 1-phenyl-2-nitropropene reacted.

5:16-6:13 - Alkalinization. The reaction proceeds with the release of heat. The remains of unreacted aluminium will additionally enter into reaction with alkali and heat the mixture, as well as create by-products.
In the process of allowing the mixture to rest after alkalinization, separation into visible layers occurs within 30 minutes. The pH of the top layer should be 11-12.

6:18-7:23 - Decantation: collect the top layer containing amphetamine base in alcohol. It can be dried a little with anhydrous magnesium sulfate, and the slag can be additionally extracted with a non-polar solvent (ether, benzene, toluene), the solvent is then evaporated.

7:24-8:50 - Preparing a solution of sulphuric acid in acetone. It is made softer acidification of the product to be smoother. If concentrated sulphuric acid is used, there may be local over-acidification of the product.

8:51-10:53 - Product acidification - obtaining amphetamine sulfate. To the upper yellow layer collected at the previous stage, a prepared solution of sulphuric acid is added dropwise. Flakes of salt will form with each drop. This stage is very important, it is necessary to carefully monitor the pH, avoiding over-acidification. Acidification is continued until pH 5.5-6 (neutral). The over-acidified product will be pinkish in colour. In case of global over-acidification, the product will be lost.

10:55-11:38 - Filtration of amphetamine sulfate from solvents in a Buchner funnel under vacuum. At this stage, the product can be additionally rinsed with cold acetone by pouring it through the funnel with the substance.

11:41-12:28 Filtration using improvised means. Any thick fabric can be used as a filter.
The resulting product is dried in a warm dry place for several hours to remove residual solvents. It is recommended to store it in a vacuum package.

The yield is 60-70%.

HIGGS BOSSONFirst of all, thank you so much for sharing your knowledge. i just have mercury chloride, HgCl2, it's works ? I need change sommething in the synsthesis ? Can you help-me ?

 

[WillD]

First of all, thank you so much for sharing your knowledge. i just have mercury chloride, HgCl2, it's works ? I need change sommething in the synsthesis ? Can you help-me ?

chubacaIt's work

 

[chubaca]

It's work

William DampierThank you very much!

 

[MilfMaker]

Does anyone here happen to be able to get me mercury nitrate?

 

[Montecristo]

Does anyone here happen to be able to get me mercury nitrate?

MilfMakerthere is a seller on amazon that ships it from ukraine.

 

[MilfMaker]

there is a seller on amazon that ships it from ukraine.

thatfellaDo you have a name or link?

 

[Montecristo]

Do you have a name or link?

MilfMaker

Mercury (II) Nitrate, Powder, 99.88%, Analytical Reagent (ACS), 25 g: Amazon.com: Industrial & Scientific

Mercury (II) Nitrate, Powder, 99.88%, Analytical Reagent (ACS), 25 g: Amazon.com: Industrial & Scientific

www.amazon.com

 

[Montecristo]

Mercury (II) Nitrate, Powder, 99.88%, Analytical Reagent (ACS), 25 g: Amazon.com: Industrial & Scientific

Mercury (II) Nitrate, Powder, 99.88%, Analytical Reagent (ACS), 25 g: Amazon.com: Industrial & Scientific

www.amazon.com

 

[Montecristo]

amazon com /Mercury-Nitrate-Powder-Analytical-Reagent/dp/B07GWW8BKS

 

[MilfMaker]

amazon com /Mercury-Nitrate-Powder-Analytical-Reagent/dp/B07GWW8BKS

thatfellathank you

Can anyone tell me where I can get sulfuric acid?

 

[MadHatter]

It depends on where you are in the world (don't answer that !!!).
If you are in a region where sulphuric acid is controlled, such as the EU, the safest way to source it is from old car batteries. Otherwise you might find battery acid sold in the hardware store.
Acid from batteries is dirty and usually one needs to at least let it stand for a week or so to let all the impurities fall to the bottom. Then you decant off the clean acid and boil it down to evaporate water (water boils at 100 C, sulphuric acid well above 300). There are several descriptions of the process here on the forum.

Obtaining sulfuric acid from battery electrolyte

Important: Observe safety procedures, when handling acids. Protect your respiratory organs and eyes! If you have battery electrolyte, you can obtain high concentrations of sulfuric acid in a simple way. This is done by evaporating the electrolyte in a sand bath. To evaporate you will need: a...

chemforum.info

Production of concentrated sulfuric acid at home

For our experience, we need a battery electrolee. I bought at once a can of 5 liters with a density of 1.28 g / cm3 (which corresponds to about 36% concentration). As probably everyone knows, the electrolyte is dilute sulfuric acid. In order to obtain more concentrated acid, we need to try to...

chemforum.info

To get clean, concentrated sulphuric acid, you need to distill it. Check youtube for this, it's not exactly dfficult but can be unsafe and produces a lot of corrosive/toxic fumes.

 

[MilfMaker]

How many % must the sulfuric acid have?

 

[Montecristo]

It depends on where you are in the world (don't answer that !!!).
If you are in a region where sulphuric acid is controlled, such as the EU, the safest way to source it is from old car batteries. Otherwise you might find battery acid sold in the hardware store.
Acid from batteries is dirty and usually one needs to at least let it stand for a week or so to let all the impurities fall to the bottom. Then you decant off the clean acid and boil it down to evaporate water (water boils at 100 C, sulphuric acid well above 300). There are several descriptions of the process here on the forum.

Obtaining sulfuric acid from battery electrolyte

Important: Observe safety procedures, when handling acids. Protect your respiratory organs and eyes! If you have battery electrolyte, you can obtain high concentrations of sulfuric acid in a simple way. This is done by evaporating the electrolyte in a sand bath. To evaporate you will need: a...

chemforum.info

Production of concentrated sulfuric acid at home

For our experience, we need a battery electrolee. I bought at once a can of 5 liters with a density of 1.28 g / cm3 (which corresponds to about 36% concentration). As probably everyone knows, the electrolyte is dilute sulfuric acid. In order to obtain more concentrated acid, we need to try to...

chemforum.info

To get clean, concentrated sulphuric acid, you need to distill it. Check youtube for this, it's not exactly dfficult but can be unsafe and produces a lot of corrosive/toxic fumes.

DocXmy still has a pipe attachment at the end to stop pressure buildup etc, can i divert the fumes into a basic mix to neutralize this? or should i just have the pipe leading outside?

 

[Montecristo]

thank you

Can anyone tell me where I can get sulfuric acid?

MilfMakerall goods man, just beware its likely deemed hazmat in most countries and likely prohibited in some, the seller doesnt ship as hazmat or as mercury though so im sure it will arrive safely ( dependant on location )

 

[MadHatter]

my still has a pipe attachment at the end to stop pressure buildup etc, can i divert the fumes into a basic mix to neutralize this? or should i just have the pipe leading outside?

thatfellaI'm sorry, your "still"? Is it a metal still? You cant boil sulphuric acid in metal, its corrosive. It will eat through your metal.
Otherwise either of the options you mentioned will work.

 

[Regtion]

Great movie! I spent a good time watching it. Where can I find more videos on how to make drugs? Do I get a link?

 

[Xiaoyan]

there is a seller on amazon that ships it from ukraine.

thatfellasorry,
you know if these vendor have aby e mail adress?

 

[Sabatier]

sorry,
you know if these vendor have aby e mail adress?

Xiaoyan[email protected]